Subtype-selective, NR2B, antagonists, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, Ro25-6981, maleate, NMDA, Receptors
Actual product may vary
Subtype-selective, NR2B, antagonists, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, Ro25-6981, maleate, NMDA, Receptors
Subtype-selective, NR2B, antagonists, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, Ro25-6981, maleate, NMDA, Receptors
Tocris Bioscience

Subtype-selective, NR2B, antagonists, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, Ro25-6981, maleate, NMDA, Receptors

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Catalog number 15941
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Ro 25-6981 maleate
Ro 25-6981 maleate is a potent and selective activity-dependent blocker of NMDA receptors containing the GluN2B (formally NR2B) subunit. IC50 values are 0.009 and 52 μM for cloned receptor subunit combinations GluN1C/GluN2B and GluN1C/GluN2A respectively. Displays neuroprotectant effects in vivo and in vitro.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

GluN2B-selective NMDA antagonist
Specifications
CAS1312991-76-6
Formula WeightObserved MW: 455.55
Quantity1 mg
Molecular FormulaC22H29NO2.C4H4O4
SolubilitySoluble to 100mM in DMSO
Chemical Name or Material(αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate
Assay Percent Range>98%
Recommended StorageDesiccate at Room Temperature
Unit SizeEA